Endocrine Abstracts

Introduction: Vasovagal syncope (VVS) is a transient loss of conscioussness due to hypoperfusion of the brain caused by vasodepressoric and/or cardioinhibitory reflex. In the pathogenesis, a dysregulation of autonomic nervous system is playing an important role. There is a growing evidence about more complex neurohumoral background of VVS. Neuropeptide Y (NPY) is hormone involved in the regulation of blood pressure with potent vasoconstriction effect. Moreover, NPY is also a c...

Objectives: Adenosine is a purinergic mediator involved in the regulation of many physiological and pathological processes. It acts as neurotransmitter in the central and autonomic nervous system, where it counterbalanaces sympathetic activity. Adenosine is produced by majority of human cellsexerting autocrine, paracrine as well as systemic effects. Due toits vasodilatatory and negative inotropic effects it seems to play a role in ethiopathogenesis of orthostatic intolerance, ...

Background: Syncope is a transient loss of consciousness resulting from cerebral hypoperfusion. Despite the extensive efforts by the scientific community over decades, the pathophysiology remains unclear. Although syncope itself is a reversible, short-lasting, benign condition, it negatively impacts quality of life. Vasovagal syncope (VVS) is a form of orthostatic intolerance (OI). Its clinical signs such as dizziness and hypotension may mimic symptoms of adrenal insufficiency...